It seem Master Chief will indeed be making a return to Halo at some point in the future. Frank O'Connor assured a crowd at Comic-Con that Chief's story wasn't finished yet.
When we left Chief at the end of Halo 3, he told Cortana, "Wake me when you need me" and went into cryosleep. In Halo 3's Legendary ending, we saw Master Chief's ship reach a mysterious planet (and O'Connor calls it a "planet" and not a ship). So what comes next?
"We'd have to be the world's biggest a**holes not to follow through," O'Connor said. "We certainly haven't seen the last of Master Chief."
Source: IGN
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